Longevity
Epithalon (10mg)
R400
Longevity
KPV (10MG)
A targeted anti-inflammatory peptide for individuals focused on gut health, immune balance, and tissue integrity.
R600
1
- Includes enough bacteriostatic water to reconstitute this vial, at no extra cost.
- Courier delivery across South Africa, 2 to 5 business days.
- Dispatched within 1 to 2 business days with tracking.
- Supplied for research and educational purposes only.
- No change-of-mind returns. Anything damaged, faulty or incorrect is replaced or refunded.
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What the research says
Alpha-MSH C-terminal tripeptide
KPV
An anti-inflammatory tripeptide with strong animal data in inflammatory bowel disease models.
- How it works
- Taken up by intestinal cells via the PepT1 transporter, where it dampens NF-kB signalling and inflammatory cytokine release.
- Research status
- Mouse colitis models; no human trials.
- Cautions
- No human safety or efficacy data.
Key studies
Reduced intestinal inflammation in mouse colitis models via PepT1-mediated uptake.
Dalmasso G et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134:166-178. doi:10.1053/j.gastro.2007.10.026
Anti-inflammatory effect in murine models of inflammatory bowel disease.
Kannengiesser K et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:324-331. doi:10.1002/ibd.20334
About this product
A targeted anti-inflammatory peptide for individuals focused on gut health, immune balance, and tissue integrity.
Lysine-Proline-Valine (KPV) 10mg is a tripeptide derived from α-MSH, recognised for its role in supporting inflammatory balance, gastrointestinal integrity, and immune regulation.
It is particularly suited for individuals seeking gentle, restorative support for the gut and immune system without systemic immune suppression.
WHAT IS LYSINE-PROLINE-VALINE (KPV)?
Lysine-Proline-Valine (KPV) is a naturally occurring tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH), known for its regulatory influence on inflammatory and immune signalling pathways.
KPV interacts with melanocortin receptors involved in immune modulation, supporting balanced cytokine activity and epithelial barrier integrity — especially within the gastrointestinal tract.
Unlike aggressive anti-inflammatory or immunosuppressive approaches, KPV supports immune regulation rather than immune shutdown.
GUT, INFLAMMATION & IMMUNE SUPPORT
Emerging research highlights KPV’s role in supporting intestinal lining integrity and reducing excessive inflammatory signalling. Chronic inflammation is commonly associated with digestive discomfort, immune stress, and impaired tissue repair.
By supporting calm immune communication and epithelial health, KPV may assist in maintaining a balanced internal environment — particularly for individuals with gut sensitivity or inflammatory stress.
KEY BENEFITS
• Supports inflammatory balance
• Aids gut lining and epithelial integrity
• Promotes immune system regulation
• Non-immunosuppressive, precision-based support
• Suitable for long-term wellness optimisation
WHO KPV IS IDEAL FOR
Lysine-Proline-Valine (KPV) is well suited for individuals who:
• Are focused on gut health and digestive balance
• Experience inflammatory or immune-related stress
• Prefer gentle, regulatory immune support
• Want non-aggressive, restorative strategies
• Are optimising long-term wellness and resilience
PRODUCT DETAILS
• Peptide: Lysine-Proline-Valine (KPV)
• Amount: 10mg per vial
• Format: Lyophilised (freeze-dried) powder
• Category: Gut Health | Immune Balance | Inflammation Support
• Storage: Refrigerate after reconstitution
WHAT YOU’LL ALSO NEED
This peptide requires reconstitution prior to use. Bacteriostatic water is included with your order for convenience.
• Reconstitution Syringe
• Insulin Syringes
• Alcohol Swabs
These essentials can be added below for convenience.
FAQ
Q: How does KPV differ from traditional anti-inflammatory approaches?
A: KPV is typically described as supporting immune regulation rather than suppressing immune function.
Q: Why is KPV often associated with gut-focused support?
A: It is commonly discussed in relation to epithelial and intestinal barrier pathways, which are closely linked to gut integrity.
Q: What makes KPV a more targeted approach?
A: It is often explored for its localised signalling effects, rather than broad systemic intervention.
IMPORTANT NOTE
This product is intended for research and educational purposes only.
Always consult a qualified healthcare professional before beginning any new peptide protocol.
