Longevity
Epithalon (10mg)
R400
Longevity
MOTS-C (40mg)
An advanced mitochondrial support peptide for individuals prioritising metabolic efficiency, cellular energy, and longevity.
R1 600
1
- Includes enough bacteriostatic water to reconstitute this vial, at no extra cost.
- Courier delivery across South Africa, 2 to 5 business days.
- Dispatched within 1 to 2 business days with tracking.
- Supplied for research and educational purposes only.
- No change-of-mind returns. Anything damaged, faulty or incorrect is replaced or refunded.
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What the research says
Mitochondrial-derived peptide
MOTS-c
An exercise-mimetic peptide encoded by mitochondrial DNA, studied for insulin sensitivity and endurance.
- How it works
- Activates AMPK signalling in muscle, improving glucose uptake and metabolic flexibility in a way that resembles the response to exercise.
- Research status
- Strong mouse data and a small first-in-human safety study of an analogue; no efficacy trials in people.
- Cautions
- No human efficacy or long-term safety data.
Key studies
Prevented diet-induced obesity and insulin resistance in mice.
Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21:443-454. doi:10.1016/j.cmet.2015.02.009
Rises with exercise in humans and improved physical performance in aged mice.
Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12:470. doi:10.1038/s41467-020-20790-0
About this product
An advanced mitochondrial support peptide for individuals prioritising metabolic efficiency, cellular energy, and longevity.
MOTS-C 40mg is a mitochondria-derived peptide designed to support metabolic flexibility, insulin sensitivity, and efficient cellular energy production. Ideal for individuals seeking improved metabolic performance, endurance, and long-term vitality rather than short-term stimulation or artificial energy boosts.
What Is MOTS-C?
MOTS-C is a unique peptide encoded by mitochondrial DNA and plays a key role in regulating whole-body energy metabolism. It functions as a metabolic signalling molecule, helping cells adapt more efficiently to nutrient availability, metabolic stress, and energy demand.
Unlike surface-level metabolic enhancers, MOTS-C works at a cellular level to support mitochondrial efficiency — the foundation of sustainable energy, metabolic resilience, and longevity.
Its mechanism makes it particularly relevant for individuals focused on long-term metabolic health rather than temporary performance hacks.
Metabolic Efficiency & Cellular Energy Support
Emerging research suggests that MOTS-C may support improved glucose utilisation, insulin sensitivity, and fatty-acid metabolism — all of which are closely linked to metabolic health and healthy ageing.
By enhancing mitochondrial signalling and metabolic adaptability, MOTS-C supports cleaner, more efficient energy production, helping the body perform better under both physical and metabolic stress.
This positions MOTS-C as a longevity-aligned peptide rather than a stimulant-based or short-lived energy solution.
Key Benefits
• Supports mitochondrial efficiency and cellular energy
• Aids metabolic flexibility and insulin sensitivity
• Promotes clean, sustainable energy production
• Supports endurance and metabolic resilience
• Longevity-aligned metabolic optimisation
Who MOTS-C Is Ideal For
MOTS-C is well suited for individuals who:
• Experience low energy despite adequate sleep and nutrition
• Want to improve metabolic efficiency and endurance
• Are focused on longevity and cellular health
• Train regularly and want cleaner energy output
• Prefer long-term metabolic optimisation over stimulants
This peptide is designed for those optimising energy at the cellular level — not chasing short-term boosts.
Product Details
• Peptide: MOTS-C
• Amount: 40mg per vial
• Format: Lyophilised (freeze-dried) powder
• Category: Metabolic Health | Longevity | Cellular Energy
• Storage: Refrigerate after reconstitution
What You’ll Also Need
This peptide requires reconstitution prior to use. Bacteriostatic water is included with your order for convenience.
• Reconstitution Syringe
• Insulin Syringes
• Alcohol Swabs
These essentials can be added below for convenience.
FAQ
Q: How does MOTS-C differ from stimulant-based energy support?
A: It is typically discussed as influencing cellular energy pathways rather than providing immediate or stimulant-driven effects.
Q: What makes MOTS-C a cellular-level approach?
A: It is often explored in relation to mitochondrial function and metabolic signalling rather than surface-level energy boosts.
Q: When is MOTS-C typically positioned within a routine?
A: It is commonly discussed as part of longer-term metabolic and performance-focused strategies rather than short-term energy use.
Important Note
This product is intended for research and educational purposes only.
Always consult a qualified healthcare professional before beginning any new peptide protocol.
