Metabolic
5-Amino-1MQ
R350
Metabolic
Retatrutide (20mg)
A powerful foundational option for individuals prioritising metabolic health and longevity.
R1 350
1
- Includes enough bacteriostatic water to reconstitute this vial, at no extra cost.
- Courier delivery across South Africa, 2 to 5 business days.
- Dispatched within 1 to 2 business days with tracking.
- Supplied for research and educational purposes only.
- No change-of-mind returns. Anything damaged, faulty or incorrect is replaced or refunded.
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What the research says
Triple GIP / GLP-1 / glucagon receptor agonist
Retatrutide
Next-generation triple agonist with the largest weight-loss effect reported in trials so far.
- How it works
- Adds glucagon receptor activity to GLP-1 and GIP agonism, which raises energy expenditure and liver fat clearance on top of appetite suppression.
- Research status
- Phase 2 obesity trial published in NEJM; the phase 3 obesity results (2025-2026) are company press releases only, and it is not an approved medicine anywhere yet.
- Timeline in the research
- Appetite changes within days; weight change builds over 12 to 48 weeks.
- Cautions
- Same class cautions as tirzepatide: thyroid C-cell tumour history, MEN2, pancreatitis.
- Heart rate increases were observed in trials; discuss with a clinician if you have a cardiac history.
- Not yet approved by any regulator, so long-term safety data are still accumulating.
Key studies
Average weight loss of 24.2% at 48 weeks on the 12 mg dose versus 2.1% on placebo (phase 2, 338 adults).
Jastreboff AM et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity: A Phase 2 Trial. N Engl J Med. 2023;389:514-526. doi:10.1056/NEJMoa2301972
Phase 3 trial in type 2 diabetes published in The Lancet in 2026; the obesity phase 3 programme (TRIUMPH) has so far reported roughly 28% average weight loss only in press releases.
Bajaj HS et al. Efficacy and safety of retatrutide in people with type 2 diabetes (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial. Lancet. 2026;407:2402-2413. doi:10.1016/S0140-6736(26)00967-0
About this product
A powerful foundational option for individuals prioritising metabolic health and longevity.
Retatrutide 20mg is a next-generation peptide designed to support metabolic health, sustainable weight management, and longevity-focused wellness. Ideal for individuals seeking long-term body composition optimisation rather than short-term weight loss alone.
What Is Retatrutide?
Retatrutide is an advanced peptide that works across multiple metabolic pathways involved in appetite regulation, insulin sensitivity, and energy utilisation. Unlike traditional single-mechanism approaches, Retatrutide supports a more comprehensive metabolic response, making it particularly relevant for those focused on whole-body metabolic health and long-term vitality.
Its unique profile positions it as a powerful option for individuals looking to improve body composition while supporting metabolic resilience over time.
Metabolic & Visceral Fat Support
Emerging research suggests that Retatrutide may play a role in reducing visceral fat and liver fat, both of which are closely linked to metabolic dysfunction, inflammation, and accelerated ageing.
Visceral fat — the fat stored around internal organs — is increasingly recognised as a key driver of insulin resistance and long-term metabolic decline. By supporting healthier fat distribution and improved metabolic signalling, Retatrutide aligns with a longevity-first approach, rather than aggressive or short-lived weight loss strategies.
This makes Retatrutide particularly appealing for individuals prioritising organ health, metabolic efficiency, and sustainable wellness.
Key Benefits
• Supports advanced metabolic function
• Aids sustainable weight management
• May assist in reducing visceral and liver fat
• Supports insulin sensitivity and energy balance
• Appetite regulation without extreme restriction
• Longevity-aligned approach to body composition
Who Retatrutide Is Ideal For
Retatrutide is well suited for individuals who:
• Carry stubborn abdominal or visceral fat despite diet and exercise
• Want to improve metabolic health, not just scale weight
• Are concerned about liver fat, insulin sensitivity, or long-term metabolic risk
• Have plateaued with traditional GLP-based approaches
• Prefer a long-term, longevity-focused strategy over quick fixes
This peptide is designed for those thinking 5–10 years ahead, not just their next milestone or event.
Product Details
• Peptide: Retatrutide
• Amount: 20mg per vial
• Format: Lyophilised (freeze-dried) powder
• Category: Weight Management | Longevity & Metabolic Health
• Storage: Refrigerate after reconstitution
What You’ll Also Need
This peptide requires reconstitution prior to use. Bacteriostatic water is included with your order for convenience.
• Reconstitution Syringe
• Insulin Syringes
• Alcohol Swabs
These essentials can be added below for convenience.
FAQ
Q: How is Retatrutide different from other metabolic peptides?
A: Retatrutide is often discussed as a multi-pathway peptide interacting with several metabolic and appetite-related systems.
Q: How does this compare to Tirzepatide?
A: Retatrutide is generally positioned as a broader metabolic optimisation approach, while Tirzepatide is more appetite-focused.
Q: What makes it a “next-level” metabolic option?
A: Its multi-pathway profile is commonly associated with more comprehensive metabolic support compared to single-mechanism approaches.
Important Note
This product is intended for research and educational purposes only.
Always consult a qualified healthcare professional before beginning any new peptide protocol.
